Document Type : Original Article

Authors

• Shabnam Shahri ¹
• Mohsen Pourfallah ²
• Mosayeb Gholinia ³

¹ Babol Noshirvani University of Technology, Babol, Iran.

² Mechanical Engineering Department, Tennessee Tech University, Cookeville, United States

³ Babol Noshirvani University of Technology, Babol, Iran

Abstract

In the current era of the availability of computational fluid dynamics tools and high-performance computers, it is possible to simulate complex physical phenomena within the human body. One of the most studied areas of this field is drug delivery. Drug path control is one of the processes that can greatly help many diseases. Using the new drug delivery system, also called “controlled release drug delivery system”, three domains of speed, time, and place of drug release can be controlled, resulting in minimizing unwanted side effects on other vital tissues, which leads to lower drug doses. This study aims to investigate the transfer of Fe3O4 nanoparticles in the presence of a magnetic field in a three-dimensional model of the Angulated Neck of Abdominal Aortic Aneurysm (AAA) extracted from the literature. The ideal aortic model includes the proximal angular neck, the aneurysm sac, and the iliac arteries. Uniform nanoparticles in a specific position relative to the angled neck of the aorta are modeled with the k - ⍵ turbulence model. The Euler- Lagrangian (E-L) approach and the magnetic hydrodynamic model (MHD) in the ANSYS solution are targeted to investigate TD nanoparticles. These nanoparticles are tracked at two different magnetic field positions located near the abdominal aorta and examined by applying different magnetic numbers

Keywords

• Drug Delivery
• Magnetic Nanoparticles
• Fe3O4
• MHD
• Abdominal Aortic Aneurysm